This plugin allows to run Minecraft commands remotely.
Project https://github.com/answering007/mcms shows how to use it with Python.

Key features:

• Send commands from Python to Spigot server
• Contains some predifined commands to work with
• Get blocks and set blocks with some NBT data
• Get server players info

Python examples: https://github.com/answering007/mcms/tree/master/examples
The project can be used for educational purposes to teach programming.